healthy soch
Dr K Aggarwal , President CMAAO, HCFI, With input from Dr Monica Vasudev : 20th January,
11am-12pm
India
healthysoch
New Delhi, January 24,, 2021
HCFI Round Table Expert Zoom Meeting on Various Mutations so far
Participants
- Dr KK Aggarwal
- Dr AK Agarwal
- Prof Mahesh Verma
- Dr Suneela Garg
- Dr Ashok Gupta
- Dr Jayakrishnan Alapet
- Dr DR Rai
- Mr Bejon Misra
- Ms Balbir Verma
- Ms Upasana Arora
- Dr KK Kalra
- Dr Suresh Mittal
- Ms Ira Gupta
- Dr S Sharma
Consensus Statement of HCFI Expert Round Table
Coronavirus has been detected in the cornea. Hence, corneal transplant is not advisable if a patient dies of covid. Early thromboembolic prophylaxis is now recommended in non-critical & Non-Hospitalized patients.
The UK Prime Minister has said that the new UK strain causes 30% more deaths. For every 1000 deaths, there are 3 additional deaths.
The current prevalent strain is D614G (aspartic acid at 614 is replaced by glycine), which increases coronavirus replication and infectivity.
The Nigeria mutation P681H (proline to histidine) is a single mutation occurring at 681 (near the S1/S2 furin cleavage site).
A mutation named N440K (asparagine to lysine) has been detected in India. This mutation is in the RBM. It is found in Andhra Pradesh (34% of genomes analyzed) and also in Karnataka, Maharashtra and Telangana.
In India, two more mutations – C1240Y and P84T – have been seen in the state of Kerala. This mutation also died out.Another mutation is in Australia S477N (serine to asparagine); this is in the RBM. This strain did not spread.
Cluster 5 mutation from Denmark, with 69/70 deletion. Diagnostics will not work with 69/70 deletion.
Then came N501Y, a spontaneous mutation occurring in immunocompromised individuals. This mutation is found in the new UK, South Africa and Brazil strains.
The UK variant VOC 2020-12/01 adopted 681 from Nigeria and 69/70 deletion from Denmark strain. There are 23 gene mutations.
The South Africa variant 501.V2; N501Y is the main; other substitutions are K417N lysine with asparagine and E484K glutamic acid with lysine. The new variant has become the predominant strain in South Africa.
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