Nearly Half of the Depression Patients Face Treatment Resistance, Study Finds

A new study published in the British Journal of Psychiatry revealed that nearly half of the patients diagnosed with depression exhibit signs of treatment-resistant depression (TRD). Led by researchers from the University of Birmingham and Birmingham and Solihull Mental Health NHS Foundation Trust, the study analyzed electronic health records and found that 48% of patients diagnosed with depression had tried at least two antidepressants, with 37% having attempted four or more treatment options.

TRD is defined as depression that remains unresponsive after two different antidepressant treatments. Despite its prevalence, there are currently limited guidelines available for managing TRD effectively.  In interviews conducted as part of the study, patients described feelings of hopelessness after multiple unsuccessful treatment attempts and expressed frustration with the one size fits all approach to treatment. The study also highlighted that patients with TRD face increased risks of other psychiatric disorders, such as anxiety, self-harm, and personality disorders, along with physical health issues like cardiovascular disease.

Data analysis indicated that patients with TRD have 35% higher odds of having a personality disorder and 46% higher odds of developing cardiovascular disease, underscoring the multiple barriers they face in achieving good health.

(Source: https://medicalxpress.com/news/2025-03-depression-treatment-resistant.html )

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