CMAAO CORONA FACTS and MYTH Various Mutations so far

January 24, 2021

Dr K Aggarwal , President CMAAO, HCFI, With input from Dr Monica Vasudev : 20th January,

11am-12pm

India

healthysoch

New Delhi, January 24,, 2021

HCFI Round Table Expert Zoom Meeting on Various Mutations so far

Participants

  • Dr KK Aggarwal
  • Dr AK Agarwal
  • Prof Mahesh Verma
  • Dr Suneela Garg
  • Dr Ashok Gupta
  • Dr Jayakrishnan Alapet
  • Dr DR Rai
  • Mr Bejon Misra
  • Ms Balbir Verma
  • Ms Upasana Arora
  • Dr KK Kalra
  • Dr Suresh Mittal
  • Ms Ira Gupta
  • Dr S Sharma

Consensus Statement of HCFI Expert Round Table

 Coronavirus has been detected in the cornea. Hence, corneal transplant is not advisable if a patient dies of covid. Early thromboembolic prophylaxis is now recommended in non-critical & Non-Hospitalized patients.

The UK Prime Minister has said that the new UK strain causes 30% more deaths. For every 1000 deaths, there are 3 additional deaths.

The current prevalent strain is D614G (aspartic acid at 614 is replaced by glycine), which increases coronavirus replication and infectivity.

The Nigeria mutation P681H (proline to histidine) is a single mutation occurring at 681 (near the S1/S2 furin cleavage site).

A mutation named N440K (asparagine to lysine) has been detected in India. This mutation is in the RBM. It is found in Andhra Pradesh (34% of genomes analyzed) and also in Karnataka, Maharashtra and Telangana.

In India, two more mutations – C1240Y and P84T – have been seen in the state of Kerala. This mutation also died out.Another mutation is in Australia S477N (serine to asparagine); this is in the RBM. This strain did not spread.

Cluster 5 mutation from Denmark, with 69/70 deletion. Diagnostics will not work with 69/70 deletion.

Then came N501Y, a spontaneous mutation occurring in immunocompromised individuals. This mutation is found in the new UK, South Africa and Brazil strains.

The UK variant VOC 2020-12/01 adopted 681 from Nigeria and 69/70 deletion from Denmark strain. There are 23 gene mutations.

The South Africa variant 501.V2; N501Y is the main; other substitutions are K417N lysine with asparagine and E484K glutamic acid with lysine. The new variant has become the predominant strain in South Africa.

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