Biomarkers in the blood may help predict recovery time after concussion

July 7, 2019

healthysoch

New Delhi, July 07, 2019 ;

Biomarkers – interleukin 6 and interleukin 1 receptor antagonist – in the blood may have potential use in identifying which players are more likely to need a longer recovery time after concussion, suggests a study published in the July 3, 2019, online issue of the journal Neurology.

The study involved 41 high school and college football players who experienced a concussion during the season. None of the players lost consciousness with their concussions. The tests looked at levels of seven biomarkers for inflammation that have been related to more severe brain injury.

Of the seven biomarkers, two – interleukin 6 and interleukin 1 receptor antagonist – were elevated for those with concussion at 6 hours after the injury compared to the athletes with no concussion. For interleukin 6, baseline levels were 0.44 pg/mL for those who later had concussions and 0.40 pg/mL for those who did not have concussions. At 6 hours after the injury, those with concussions had levels of 1.01 pg/mL, compared to levels of 0.39 at a similar time for those without concussions.

Athletes with higher levels of interleukin 6 six hours after the injury were also more likely to take longer to recover from their symptoms. Eight of the 17 athletes with concussion and high interleukin 6 levels at six hours after injury, compared to their levels at the beginning of the season, still had concussion symptoms eight days after the injury.

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