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Dr K K Aggarwal ,President CMAAO, HCFI and Past National President CMAAO
New Delhi, March 30, 2020 :
COVID can not occur in animals : The human infectious dose of SARSCoV-2, which causes coronavirus disease 19 (COVID-19) is currently unknown via all exposure routes. Animal data are used as surrogates.
Rhesus macaques are infected with SARS-CoV-2 via the ocular conjunctival and intratracheal route at a dose of 700,000 PFU. A total dose of 700,000 plaque forming units (PFU) of SARS-CoV-2 infected cynomolgus macaques via a combination intranasal and intratracheal exposure (106 TCID50 total dose). Macaques did not exhibit clinical symptoms, but shed virus through the nose and throat.
Nonhuman primate infection may not represent human infection. Initial experiments suggest that SARSCoV-2 can infect genetically modified mice containing the human ACE2 cell entry receptor. Infection via the intranasal route (dose: 105 TCID50, approximately 70,000 PFU) causes light infection, however no virus was isolated from infected animals, and polymerase chain reaction (PCR) primers used in the study do not align well with SARS-CoV-2, casting doubt on this study.
The infectious dose for SARS in mice is estimated to be between 67-540 PFU (average 240 PFU, intranasal route). Genetically modified mice exposed intranasally to doses of MERS virus between 100 and 500,000 PFU show signs of infection. Infection with higher doses result in severe syndromes.
We have no data that it can infect animals : Modelling between SARS-CoV-2 Spike and ACE2 proteins suggests that SARS-CoV-2 can bind and infect human, bat, civet, monkey and swine cells.129 • There is
Wan, Y.; Shang, J.; Graham, R.; Baric, R. S.; Li, F., Receptor recognition by novel coronavirus from Wuhan: An analysis based on decadelong structural studies of SARS. Journal of Virology 2020, JVI.00127-20.
How does it matter if animals gets or not : It matters,. We can make the vaccine, antibodies serum from them. And if we believe in Vedas we can leave these infected animals in the jungle to see which plants they eat and that may be the cure for that virus.
https://www.thoracic.org/about/newsroom/press-releases/journal/2020/some-covid-19-patients-still-have-coronavirus-after-symptoms-disappear.php
No. In a new study, researchers found that half of the patients they treated for mild COVID-19 infection still had coronavirus for up to eight days after symptoms disappeared. The research letter was published online in the American Thoracic Society’s American Journal of Respiratory and Critical Care Medicine. More severe infections may have even longer shedding times.
The time from infection to onset of symptoms (incubation period) was five days among all but one patient. The average duration of symptoms was eight days, while the length of time patients remained contagious after the end of their symptoms ranged from one to eight days. Two patients had diabetes and one had tuberculosis, neither of which affected the timing of the course of COVID-19 infection.
The disease is uniformly distributed : No. Just four countries account for over half the Covid-19 cases globally. USA, Italy, Spain and china. These four nations are home to a quarter of the world’s population and control two-fifths of the global economy, considering their share of the world gross domestic product (GDP). While China alone makes up a fifth of the global population, the US accounts for almost 25% of the world GDP
Turkey is under control :Turkey recorded its first coronavirus case only on March 11, but the number of cases and deaths there have been growing rapidly since. Turkey is doubling the Covid-19 infected cases each day. By comparison, India is doubling every 3.5 days.
Kerala is the focus of infection : One district — Kasargod is the hot spot. On Friday alone, the state saw 39 new Covid-19 cases, of which 34 were from this one district. One of Kerala’s 14 districts and having a population of around 1.3 million, Kasaragod has been under a total lockdown since March 21.
The test is possible on day 1 : No. we do not know. Eclipse phase of infection (time between infection and detectable disease) in an individual is not known.
PPE surfaces can not transmit infections :Stability of SARS-CoV-2 on PPE (e.g., Tyvek, nitrile, etc. is not known.
Corticosteroids can be given to COVID-19 patients : Corticosteroids are commonly given to COVID-19 patients153 at risk of ARDS,146 but their use is not recommended by the US CDC.29
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