admin
Revisiting Metastatic Endometrial Cancer
New Delhi,July 18, 2018 :
For women with newly-diagnosed, metastatic endometrial cancer that are felt to have operable disease, one should go for surgical cytoreduction
For those who undergo surgery one should administer of adjuvant chemotherapy following surgery with carboplatin and
For some women with metastatic endometrial cancer, endocrine therapy (for megestrol acetate alternating with tamoxifen) is a reasonable alternative to combination chemotherapy if any of the following factors are present: grade 1 or 2 endometrial cancer, tumors positive for estrogen (ER) and progesterone (PR) receptors, and women without (or with minimal) cancer-related symptoms.
For those who progress after front-line endocrine therapy, a platinum-based combination regimen may be offered.
For women who progress six months or longer after a prior line of chemotherapy, repeat treatment with a platinum-based combination, although endocrine therapy is an appropriate alternative.
For women who progress less than six months from their prior regimen, one can offer either single-agent therapy or endocrine therapy.
The prognosis of women who experience disease progression following first- or second-line therapy is poor.
The prognosis of endometrial carcinoma is determined primarily by disease stage and histology (including both grade and histologic subtype). In general, the rate of five-year survival for stage I disease is approximately 80 to 90 percent, for stage II it is 70 to 80 percent, and for stages III and IV it is 20 to 60 percent. Metastasis is IVb (21.1%).
FDA Recalls Valsartan Over Potential Cancer Risk
22 countries have recalled Valsartan, now off label, as it contains a chemical NDMA (N-nitrosodimethylamine) impurity that poses a potential cancer risk.
NDMA is an organic carcinogen chemical commonly used to make liquid rocket fuel, softeners and lubricants, among other products. It can also be unintentionally produced through certain chemical reactions and is a byproduct from some pesticide manufacturing, the making of rubber tires or fish processing.
Animal studies have shown that NDMA can cause tumors in the liver, kidney and respiratory tract. Exposure to high levels can cause liver damage and is a probable human carcinogen.
MEDtalks: The risk of gastric cancer associated with dietary intake of nitrites and nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds was investigated in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. While there was no association between intake of nitrites and NMDA and gastric cancer risk, endogenous production of N-nitroso compounds was significantly associated with non-cardia cancer risk (Carcinogenesis 2006; 27:1497.).
Dr KK Aggarwal
Padma Shri Awardee
Vice President CMAAO
President HCFI
HealthySoch
